Skip to main content English

Publikationen

 

Widder S, Görzer I, Friedel B, Rahimi N, Schwarz S, Jaksch P, Knapp S, Puchhammer-Stöckl E. Microbiome. Metagenomic sequencing reveals time, host, and body compartment-specific viral dynamics after lung transplantation. 2022 Apr 23;10(1):66. doi: 10.1186/s40168-022-01244-9.

 

Shoemaker RH, Panettieri RA Jr, Libutti SK, Hochster HS, Watts NR, Wingfield PT, Starkl P, Pimenov L, Gawish R, Hladik A, Knapp S, Boring D, White JM, Lawrence Q, Boone J, Marshall JD, Matthews RL, Cholewa BD, Richig JW, Chen BT, McCormick DL, Gugensberger R, Höller S, Penninger JM, Wirnsberger G. Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer. PLoS One. 2022 Jul 11;17(7):e0271066. doi: 10.1371/journal.pone.0271066. eCollection 2022.

 

Zahalka S, Starkl P, Watzenboeck ML, Farhat A, Radhouani M, Deckert F, Hladik A, Lakovits K, Oberndorfer F, Lassnig C, Strobl B, Klavins K, Matsushita M, Sanin DE, Grzes KM, Pearce EJ, Gorki AD, Knapp S. Mucosal Immunol. Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling. 2022 May;15(5):896-907. doi: 10.1038/s41385-022-00528-5. Epub 2022 Jul 18.

 

Watzenboeck, M. L., Gorki, A. D., Quattrone, F., Gawish, R., Schwarz, S., Lambers, C., Jaksch, P., Lakovits, K., Zahalka, S., Rahimi, N., Starkl, P., Symmank, D., Artner, T., Pattaroni, C., Fortelny, N., Klavins, K., Frommlet, F., Marsland, B. J., Hoetzenecker, K., Widder, S., and Knapp, S. (2022) Multi-omics profiling predicts allograft function after lung transplantation. Eur Respir J 59

 

Starkl, P., Gaudenzio, N., Marichal, T., Reber, L. L., Sibilano, R., Watzenboeck, M. L., Fontaine, F., Mueller, A. C., Tsai, M., Knapp, S., and Galli, S. J. (2022) IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells. Allergy 77, 499-512

 

Gorki, A. D., Symmank, D., Zahalka, S., Lakovits, K., Hladik, A., Langer, B., Maurer, B., Sexl, V., Kain, R., and Knapp, S. (2022) Murine Ex Vivo Cultured Alveolar Macrophages Provide a Novel Tool to Study Tissue-Resident Macrophage Behavior and Function. Am J Respir Cell Mol Biol 66, 64-75

 

Gawish, R., Starkl, P., Pimenov, L., Hladik, A., Lakovits, K., Oberndorfer, F., Cronin, S. J., Ohradanova-Repic, A., Wirnsberger, G., Agerer, B., Endler, L., Capraz, T., Perthold, J. W., Cikes, D., Koglgruber, R., Hagelkruys, A., Montserrat, N., Mirazimi, A., Boon, L., Stockinger, H., Bergthaler, A., Oostenbrink, C., Penninger, J. M., and Knapp, S. (2022) ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNgamma-driven immunopathology. Elife 11, e74623

 

Watzenboeck, M. L., Drobits, B., Zahalka, S., Gorki, A. D., Farhat, A., Quattrone, F., Hladik, A., Lakovits, K., Richard, G. M., Lederer, T., Strobl, B., Versteeg, G. A., Boon, L., Starkl, P., and Knapp, S. (2021) Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner. PLoS pathogens 17, e1009487

 

Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, Starkl P, Balbino B, Roers A, Bruhns P, Jönsson F, Moguelet P, Georgin-Lavialle S, Broderick L, Hoffman HM, Galli SJ, Reber LL. J Exp Med. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. 2021 Oct 4;218(10):e20201466. doi: 10.1084/jem.20201466,

 

Widder S, Zhao J, Carmody LA, Zhang Q, Kalikin LM, Schloss PD, LiPuma JJ. Association of bacterial community types, functional microbial processes and lung disease in cystic fibrosis airways. ISME J. 2022 Apr;16(4):905-914. doi: 10.1038/s41396-021-01129-z. Epub 2021 Oct 23.

 

Sharif, O., Brunner, J. S., Korosec, A., Martins, R., Jais, A., Snijder, B., Vogel, A., Caldera, M., Hladik, A., Lakovits, K., Saluzzo, S., Boehm, B., Gorki, A. D., Mesteri, I., Lindroos-Christensen, J., Tillmann, K., Stoiber, D., Menche, J., Schabbauer, G., Bilban, M., Superti-Furga, G., Esterbauer, H., and Knapp, S. (2021) Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages. Diabetes 70, 2042-2057

 

Schwarz, S., Rahimi, N., Kifjak, D., Muckenhuber, M., Watzenbock, M., Benazzo, A., Jaksch, P., Knapp, S., Klepetko, W., Hoetzenecker, K., and Vienna Lung Transplant, G. (2021) Comparison of donor scores in bilateral lung transplantation-A large single-center analysis. Am J Transplant 21, 2132-2144

 

Sandner, L., Alteneder, M., Zhu, C., Hladik, A., Hogler, S., Rica, R., Van Greuningen, L. W., Sharif, O., Sakaguchi, S., Knapp, S., Kenner, L., Trauner, M., Ellmeier, W., and Boucheron, N. (2021) The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation. Front Immunol 12, 750466

 

Ramirez-Moral, I., Blok, D. C., Bernink, J. H., Garcia-Laorden, M. I., Florquin, S., Boon, L., Van't Veer, C., Mack, M., Saluzzo, S., Knapp, S., Spits, H., de Vos, A. F., and van der Poll, T. (2021) Interleukin-33 improves local immunity during Gram-negative pneumonia by a combined effect on neutrophils and inflammatory monocytes. J Pathol 253, 374-383

 

Esparza-Baquer, A., Labiano, I., Sharif, O., Agirre-Lizaso, A., Oakley, F., Rodrigues, P. M., Zhuravleva, E., O'Rourke, C. J., Hijona, E., Jimenez-Aguero, R., Riano, I., Landa, A., La Casta, A., Zaki, M. Y. W., Munoz-Garrido, P., Azkargorta, M., Elortza, F., Vogel, A., Schabbauer, G., Aspichueta, P., Andersen, J. B., Knapp, S., Mann, D. A., Bujanda, L., Banales, J. M., and Perugorria, M. J. (2021) TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. Gut 70, 1345-1361

 

Ubags, N. D. J., Alejandre Alcazar, M. A., Kallapur, S. G., Knapp, S., Lanone, S., Lloyd, C. M., Morty, R. E., Pattaroni, C., Reynaert, N. L., Rottier, R. J., Smits, H. H., de Steenhuijsen Piters, W. A. A., Strickland, D. H., and Collins, J. J. P. (2020) Early origins of lung disease: towards an interdisciplinary approach. Eur Respir Rev 29

 

Starkl, P., Watzenboeck, M. L., Popov, L. M., Zahalka, S., Hladik, A., Lakovits, K., Radhouani, M., Haschemi, A., Marichal, T., Reber, L. L., Gaudenzio, N., Sibilano, R., Stulik, L., Fontaine, F., Mueller, A. C., Amieva, M. R., Galli, S. J., and Knapp, S. (2020) IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcusaureus. Immunity 53, 793-804.e799

 

Lang, C., Jaksch, P., Hoda, M. A., Lang, G., Staudinger, T., Tschernko, E., Zapletal, B., Geleff, S., Prosch, H., Gawish, R., Knapp, S., Robak, O., Thalhammer, F., Indra, A., Koestenberger, M., Strassl, R., Klikovits, T., Ali, K., Fischer, G., Klepetko, W., Hoetzenecker, K., and Schellongowski, P. (2020) Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient. The Lancet. Respiratory medicine

 

Knapp, S. (2020) Vaping: Cell Damage at the Receiving ENDS. Am J Respir Cell Mol Biol 63, 271-272

 

Hainberger, D., Stolz, V., Zhu, C., Schuster, M., Muller, L., Hamminger, P., Rica, R., Waltenberger, D., Alteneder, M., Krausgruber, T., Hladik, A., Knapp, S., Bock, C., Trauner, M., Farrar, M. A., and Ellmeier, W. (2020) NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4(+) T Cells. Front Immunol 11, 579

 

Goschl, L., Preglej, T., Boucheron, N., Saferding, V., Muller, L., Platzer, A., Hirahara, K., Shih, H. Y., Backlund, J., Matthias, P., Niederreiter, B., Hladik, A., Kugler, M., Gualdoni, G. A., Scheinecker, C., Knapp, S., Seiser, C., Holmdahl, R., Tillmann, K., Plasenzotti, R., Podesser, B., Aletaha, D., Smolen, J. S., Karonitsch, T., Steiner, G., Ellmeier, W., and Bonelli, M. (2020) Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J Autoimmun 108, 102379

 

Widder, S., and Knapp, S. (2019) Microbial Metabolites in Cystic Fibrosis: A Target for Future Therapy? Am J Respir Cell Mol Biol 61, 132-133

 

Libert, C., Ayala, A., Bauer, M., Cavaillon, J. M., Deutschman, C., Frostell, C., Knapp, S., Kozlov, A. V., Wang, P., Osuchowski, M. F., and Remick, D. G. (2019) Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints. Shock (Augusta, Ga 51, 23-32

 

Kral-Pointner, J. B., Schrottmaier, W. C., Salzmann, M., Mussbacher, M., Schmidt, G. J., Moser, B., Heber, S., Birnecker, B., Paar, H., Zellner, M., Knapp, S., Assinger, A., and Schabbauer, G. (2019) Platelet PI3K Modulates Innate Leukocyte Extravasation during Acid-Induced Acute Lung Inflammation. Thromb Haemost 19, 1642-1654

 

Klufa, J., Bauer, T., Hanson, B., Herbold, C., Starkl, P., Lichtenberger, B., Srutkova, D., Schulz, D., Vujic, I., Mohr, T., Rappersberger, K., Bodenmiller, B., Kozakova, H., Knapp, S., Loy, A., and Sibilia, M. (2019) Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy. Sci Transl Med 11

 

Andersen, L., Gulich, A. F., Alteneder, M., Preglej, T., Orola, M. J., Dhele, N., Stolz, V., Schebesta, A., Hamminger, P., Hladik, A., Floess, S., Krausgruber, T., Faux, T., Andrabi, S. B. A., Huehn, J., Knapp, S., Sparwasser, T., Bock, C., Laiho, A., Elo, L. L., Rasool, O., Lahesmaa, R., Sakaguchi, S., and Ellmeier, W. (2019) The Transcription Factor

MAZR/PATZ1 Regulates the Development of FOXP3(+) Regulatory T Cells. Cell reports 29, 4447-4459 e4446

 

Perugorria, M. J., Esparza-Baquer, A., Oakley, F., Labiano, I., Korosec, A., Jais, A., Mann, J., Tiniakos, D., Santos-Laso, A., Arbelaiz, A., Gawish, R., Sampedro, A., Fontanellas, A., Hijona, E., Jimenez-Aguero, R., Esterbauer, H., Stoiber, D., Bujanda, L., Banales, J. M., Knapp, S., Sharif, O., and Mann, D. A. (2018) Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage. Gut

 

Faust K, Bauchinger F, Laroche B, de Buyl S, Lahti L, Washburne AD, Gonze D, Widder S. Signatures of ecological processes in microbial community time series.Microbiome. 2018 Jun 28;6(1):120. doi: 10.1186/s40168-018-0496-2.

 

Pattaroni, C., Watzenboeck, M. L., Schneidegger, S., Kieser, S., Wong, N. C., Bernasconi, E., Pernot, J., Mercier, L., Knapp, S., Nicod, L. P., Marsland, C. P., Roth-Kleiner, M., and Marsland, B. J. (2018) Early-Life Formation of the Microbial and Immunological Environment of the Human Airways. Cell Host Microbe 24, 857-865 e854

 

Osuchowski, M. F., Ayala, A., Bahrami, S., Bauer, M., Boros, M., Cavaillon, J. M., Chaudry, I. H., Coopersmith, C. M., Deutschman, C. S., Drechsler, S., Efron, P., Frostell, C., Fritsch, G., Gozdzik, W., Hellman, J., Huber-Lang, M., Inoue, S., Knapp, S., Kozlov, A. V., Libert, C., Marshall, J. C., Moldawer, L. L., Radermacher, P., Redl, H., Remick, D. G., Singer, M., Thiemermann, C., Wang, P., Wiersinga, W. J., Xiao, X., and Zingarelli, B. (2018) Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Shock (Augusta, Ga 50, 377-380

 

Osuchowski, M. F., Ayala, A., Bahrami, S., Bauer, M., Boros, M., Cavaillon, J. M., Chaudry, I. H., Coopersmith, C. M., Deutschman, C., Drechsler, S., Efron, P., Frostell, C., Fritsch, G., Gozdzik, W., Hellman, J., Huber-Lang, M., Inoue, S., Knapp, S., Kozlov, A. V., Libert, C., Marshall, J. C., Moldawer, L. L., Radermacher, P., Redl, H., Remick, D. G., Singer, M., Thiemermann, C., Wang, P., Wiersinga, W. J., Xiao, X., and Zingarelli, B. (2018) Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection 46, 687-691

 

Osuchowski, M. F., Ayala, A., Bahrami, S., Bauer, M., Boros, M., Cavaillon, J. M., Chaudry, I. H., Coopersmith, C. M., Deutschman, C., Drechsler, S., Efron, P., Frostell, C., Fritsch, G., Gozdzik, W., Hellman, J., Huber-Lang, M., Inoue, S., Knapp, S., Kozlov, A. V., Libert, C., Marshall, J. C., Moldawer, L. L., Radermacher, P., Redl, H., Remick, D. G., Singer, M., Thiemermann, C., Wang, P., Wiersinga, W. J., Xiao, X., and Zingarelli, B. (2018) Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Intensive Care Med Exp 6, 26

 

Martins, R., and Knapp, S. (2018) Heme and hemolysis in innate immunity: adding insult to injury. Curr Opin Immunol 50, 14-20

 

Knapp, S. (2018) theta-Defensins-A Magic Bullet for Acute Lung Injury? Am J Respir Cell Mol Biol 58, 277-278

 

Cohen, M., Giladi, A., Gorki, A. D., Solodkin, D. G., Zada, M., Hladik, A., Miklosi, A., Salame, T. M., Halpern, K. B., David, E., Itzkovitz, S., Harkany, T., Knapp, S., and Amit, I. (2018) Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting. Cell 175, 1031-1044 e1018

 

Saluzzo, S., Gorki, A. D., Rana, B. M., Martins, R., Scanlon, S., Starkl, P., Lakovits, K., Hladik, A., Korosec, A., Sharif, O., Warszawska, J. M., Jolin, H., Mesteri, I., McKenzie, A. N., and Knapp, S. (2017) First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment. Cell reports 18, 1893-1905

 

Kral-Pointner, J. B., Schrottmaier, W. C., Horvath, V., Datler, H., Hell, L., Ay, C., Niederreiter, B., Jilma, B., Schmid, J. A., Assinger, A., Mackman, N., Knapp, S., and Schabbauer, G. (2017) Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury. J Thromb Haemost 15, 1625-1639

 

Kosack, L., Gawish, R., Lercher, A., Vilagos, B., Hladik, A., Lakovits, K., Bhattacharya, A., Schliehe, C., Mesteri, I., Knapp, S., and Bergthaler, A. (2017) The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis. Sci Rep 7, 11289

 

Busch, C. J., Hendrikx, T., Weismann, D., Jackel, S., Walenbergh, S. M., Rendeiro, A. F., Weisser, J., Puhm, F., Hladik, A., Goderle, L., Papac-Milicevic, N., Haas, G., Millischer, V., Subramaniam, S., Knapp, S., Bennett, K. L., Bock, C., Reinhardt, C., Shiri-Sverdlov, R., and Binder, C. J. (2017) Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology 65, 1181-1195

 

Willmann, K. L., Sacco, R., Martins, R., Garncarz, W., Krolo, A., Knapp, S., Bennett, K. L., and Boztug, K. (2016) Expanding the Interactome of the Noncanonical NF-kappaB Signaling Pathway. J Proteome Res 15, 2900-2909

 

Martins, R., Maier, J., Gorki, A. D., Huber, K. V., Sharif, O., Starkl, P., Saluzzo, S., Quattrone, F., Gawish, R., Lakovits, K., Aichinger, M. C., Radic-Sarikas, B., Lardeau, C. H., Hladik, A., Korosec, A., Brown, M., Vaahtomeri, K., Duggan, M., Kerjaschki, D., Esterbauer, H., Colinge, J., Eisenbarth, S. C., Decker, T., Bennett, K. L., Kubicek, S., Sixt, M., Superti-Furga, G., and Knapp, S. (2016) Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions. Nature immunology 17, 1361-1372

 

Maier, B. B., Hladik, A., Lakovits, K., Korosec, A., Martins, R., Kral, J. B., Mesteri, I., Strobl, B., Muller, M., Kalinke, U., Merad, M., and Knapp, S. (2016) Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice. European journal of immunology 46, 2175-2186

 

Kral, J. B., Kuttke, M., Schrottmaier, W. C., Birnecker, B., Warszawska, J., Wernig, C., Paar, H., Salzmann, M., Sahin, E., Brunner, J. S., Osterreicher, C., Knapp, S., Assinger, A., and Schabbauer, G. (2016) Sustained PI3K Activation exacerbates BLM-induced Lung Fibrosis via activation of pro-inflammatory and pro-fibrotic pathways. Sci Rep 6, 23034

 

Knapp, S. (2016) Gut to lung. Gut 65, 544-545

 

Doehn, J. M., Winkler, A., Kuzmina, Z., Hladik, A., Greinix, H., Knapp, S., and Robak, O. (2016) Pentraxin-3 levels in graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. Exp Hematol

 

Castiglia, V., Piersigilli, A., Ebner, F., Janos, M., Goldmann, O., Dambock, U., Kroger, A., Weiss, S., Knapp, S., Jamieson, A. M., Kirschning, C., Kalinke, U., Strobl, B., Muller, M., Stoiber, D., Lienenklaus, S., and Kovarik, P. (2016) Type I Interferon Signaling Prevents IL-1beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue. Cell Host Microbe 19, 375-387

 

Schliehe, C., Flynn, E. K., Vilagos, B., Richson, U., Swaminathan, S., Bosnjak, B., Bauer, L., Kandasamy, R. K., Griesshammer, I. M., Kosack, L., Schmitz, F., Litvak, V., Sissons, J., Lercher, A., Bhattacharya, A., Khamina, K., Trivett, A. L., Tessarollo, L., Mesteri, I., Hladik, A., Merkler, D., Kubicek, S., Knapp, S., Epstein, M. M., Symer, D. E., Aderem, A., and Bergthaler, A. (2015) The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nature immunology 16, 67-74

 

Prochazkova, J., Sakaguchi, S., Owusu, M., Mazouzi, A., Wiedner, M., Velimezi, G., Moder, M., Turchinovich, G., Hladik, A., Gurnhofer, E., Hayday, A., Behrens, A., Knapp, S., Kenner, L., Ellmeier, W., and Loizou, J. I. (2015) DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation. PLoS genetics 11, e1005645

Matt, U., Sharif, O., Martins, R., and Knapp, S. (2015) Accumulating evidence for a role of oxidized phospholipids in infectious diseases. Cellular and molecular life sciences : CMLS 72, 1059-1071

 

Kulinski, T. M., Casari, M. R., Guenzl, P. M., Wenzel, D., Andergassen, D., Hladik, A., Datlinger, P., Farlik, M., Theussl, H. C., Penninger, J. M., Knapp, S., Bock, C., Barlow, D. P., and Hudson, Q. J. (2015) Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Developmental biology 402, 291-305

 

Heinz, L. X., Baumann, C. L., Koberlin, M. S., Snijder, B., Gawish, R., Shui, G., Sharif, O., Aspalter, I. M., Muller, A. C., Kandasamy, R. K., Breitwieser, F. P., Pichlmair, A., Bruckner, M., Rebsamen, M., Bluml, S., Karonitsch, T., Fauster, A., Colinge, J., Bennett, K. L., Knapp, S., Wenk, M. R., and Superti-Furga, G. (2015) The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell reports 11, 1919-1928

 

Gawish, R., Martins, R., Bohm, B., Wimberger, T., Sharif, O., Lakovits, K., Schmidt, M., and Knapp, S. (2015) Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29, 1247-1257

 

Blatt, K., Cerny-Reiterer, S., Schwaab, J., Sotlar, K., Eisenwort, G., Stefanzl, G., Hoermann, G., Mayerhofer, M., Schneeweiss, M., Knapp, S., Rulicke, T., Hadzijusufovic, E., Bauer, K., Smiljkovic, D., Willmann, M., Reiter, A., Horny, H. P., and Valent, P. (2015) Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis. Blood 126, 2832-2841

 

Sharif, O., Gawish, R., Warszawska, J. M., Martins, R., Lakovits, K., Hladik, A., Doninger, B., Brunner, J., Korosec, A., Schwarzenbacher, R. E., Berg, T., Kralovics, R., Colinge, J., Mesteri, I., Gilfillan, S., Salmaggi, A., Verschoor, A., Colonna, M., and Knapp, S. (2014) The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. PLoS pathogens 10, e1004167

 

Koffel, R., Meshcheryakova, A., Warszawska, J., Hennig, A., Wagner, K., Jorgl, A., Gubi, D., Moser, D., Hladik, A., Hoffmann, U., Fischer, M. B., van den Berg, W., Koenders, M., Scheinecker, C., Gesslbauer, B., Knapp, S., and Strobl, H. (2014) Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation. Blood 124, 2713-2724

 

Jais, A., Einwallner, E., Sharif, O., Gossens, K., Lu, T. T., Soyal, S. M., Medgyesi, D., Neureiter, D., Paier-Pourani, J., Dalgaard, K., Duvigneau, J. C., Lindroos-Christensen, J., Zapf, T. C., Amann, S., Saluzzo, S., Jantscher, F., Stiedl, P., Todoric, J., Martins, R., Oberkofler, H., Muller, S., Hauser-Kronberger, C., Kenner, L., Casanova, E., Sutterluty-Fall, H., Bilban, M., Miller, K., Kozlov, A. V., Krempler, F., Knapp, S., Lumeng, C. N., Patsch, W., Wagner, O., Pospisilik, J. A., and Esterbauer, H. (2014) Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man. Cell 158, 25-40

Zielinski, C., Knapp, S., Mascaux, C., and Hirsch, F. (2013) Rationale for targeting the immune system through checkpoint molecule blockade in the treatment of non-small-cell lung cancer. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 24, 1170-1179

 

Warszawska, J. M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., Fuhrmann, V., Strobl, B., Muller, M., Schenk, P., Weiss, G., and Knapp, S. (2013) Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest 123, 3363-3372

 

Sharif, O., Matt, U., Saluzzo, S., Lakovits, K., Haslinger, I., Furtner, T., Doninger, B., and Knapp, S. (2013) The scavenger receptor CD36 downmodulates the early inflammatory response while enhancing bacterial phagocytosis during pneumococcal pneumonia. J Immunol 190, 5640-5648

 

Matt, U., Sharif, O., Martins, R., Furtner, T., Langeberg, L., Gawish, R., Elbau, I., Zivkovic, A., Lakovits, K., Oskolkova, O., Doninger, B., Vychytil, A., Perkmann, T., Schabbauer, G., Binder, C. J., Bochkov, V. N., Scott, J. D., and Knapp, S. (2013) WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. J Clin Invest 123, 3014-3024

 

Knapp, S. (2013) Diabetes and infection: is there a link?--A mini-review. Gerontology 59, 99-104

 

Burckstummer, T., Banning, C., Hainzl, P., Schobesberger, R., Kerzendorfer, C., Pauler, F. M., Chen, D., Them, N., Schischlik, F., Rebsamen, M., Smida, M., Fece de la Cruz, F., Lapao, A., Liszt, M., Eizinger, B., Guenzl, P. M., Blomen, V. A., Konopka, T., Gapp, B., Parapatics, K., Maier, B., Stockl, J., Fischl, W., Salic, S., Taba Casari, M. R., Knapp, S., Bennett, K. L., Bock, C., Colinge, J., Kralovics, R., Ammerer, G., Casari, G., Brummelkamp, T. R., Superti-Furga, G., and Nijman, S. M. (2013) A reversible gene trap collection empowers haploid genetics in human cells. Nat Methods 10, 965-971

 

Sigel, S., Bunk, S., Meergans, T., Doninger, B., Stich, K., Stulnig, T., Derfler, K., Hoffmann, J., Deininger, S., von Aulock, S., and Knapp, S. (2012) Apolipoprotein B100 is a suppressor of Staphylococcus aureus-induced innate immune responses in humans and mice. European journal of immunology 42, 2983-2989

 

Laimer, D., Dolznig, H., Kollmann, K., Vesely, P. W., Schlederer, M., Merkel, O., Schiefer, A. I., Hassler, M. R., Heider, S., Amenitsch, L., Thallinger, C., Staber, P. B., Simonitsch-Klupp, I., Artaker, M., Lagger, S., Turner, S. D., Pileri, S., Piccaluga, P. P., Valent, P., Messana, K., Landra, I., Weichhart, T., Knapp, S., Shehata, M., Todaro, M., Sexl, V., Hofler, G., Piva, R., Medico, E., Ruggeri, B. A., Cheng, M., Eferl, R., Egger, G., Penninger, J. M., Jaeger, U., Moriggl, R., Inghirami, G., and Kenner, L. (2012) PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nat Med 18, 1699-1704

 

Zivkovic, A., Sharif, O., Stich, K., Doninger, B., Biaggio, M., Colinge, J., Bilban, M., Mesteri, I., Hazemi, P., Lemmens-Gruber, R., and Knapp, S. (2011) TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivo. J Immunol 186, 1608-1617